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Vicodin is supplied in tablet form for oral administration. Hydrocodone bitartrate is an opioid analgesic and antitussive and occurs as fine, white crystals or as a crystalline powder. It is affected by light. The chemical name is 4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5). It has the following structural formula: Acetaminophen, 4´-Hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. It has the following structural formula. Vicodin (hydrocodone bitartrate and acetaminophen) is a narcotic analgesic. it is prescribed to relieve moderate to moderately severe pain. Researchers believe that the ingredient hydrocodone relieves pain by changing how the brain and nervous system respond to painful stimuli.
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Signs of Overdose
Signs and symptoms of overdose include respiratory depression, extreme sleepiness that progresses to coma, skeletal muscle flaccidity (limpness), cold or clammy skin, bradycardia (slow heartbeat), and hypotension (low blood pressure). With very severe overdose, there can be apnea, circulatory collapse, cardiac arrest, and death. The acetaminophen portion can result in fatal hepatic necrosis, renal tubular necrosis, hypoglycemic coma, and thrombocytopenia (low platelets).
Common Side Effects
Some of the common side effects that may be associated with hydrocodone/acetaminophen include:
There are also adverse events related to the central nervous system, gastrointestinal system, genitourinary system, respiratory system, the senses, and dermatology:
Central nervous system: drowsiness, lethargy, cloudy thinking, impairment of mental and physical performance, anxiety, fear, dysphoria, mood changes, and psychic dependence
Gastrointestinal: constipation with prolonged use
Genitourinary: ureteral spasm, bladder sphincter spasm, urinary retention
Respiratory: respiratory depression that is dose-related
Special senses: hearing impairment or hearing loss related to chronic overdose
Dermatology: skin rash, pruritis
Warnings and Precautions
Hydrocodone/acetaminophen should be used with caution in the elderly population and with debilitated patients, patients with severe liver or kidney impairment, hypothyroidism, Addison’s disease, prostatic hypertrophy, or urethral stricture. It should always be remembered that there is the potential for respiratory depression and that the drug suppresses the cough mechanism.
Patients should use caution when driving and operating machinery while taking hydrocodone/acetaminophen. The drug can be habit-forming, so being aware of your dose will serve you well.